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Bizine

Axon 2306
  • Parent CAS:  1591932-50-1
Purity:  98%
  • Soluble in water and DMSO
  • MF:  C18H23N3O.HCl
  • MW:  333.86

Description

Potent LSD1 inhibitor in vitro and selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2 with Ki(inact) values 0.059 μM, 2.6 μM, 6.5 μM, and ca 11 μM for LSD1, MAO-A, MAO-B, and LSD2 respectively. Bizine was found to be effective at modulating bulk histone methylation in cancer cells. Moreover, neurons exposed to oxidative stress were protected by the presence of bizine, suggesting potential applications in neurodegenerative disease.

More Information

Parent CAS No. 1591932-50-1
Chemical Name N-(4-(2-hydrazinylethyl)phenyl)-4-phenylbutanamide hydrochloride
SMILES C1(CCCC(NC2=CC=C(CCNN)C=C2)=O)=CC=CC=C1.Cl
MFCD N.A.
InChi InChI=1S/C18H23N3O.ClH/c19-20-14-13-16-9-11-17(12-10-16)21-18(22)8-4-7-15-5-2-1-3-6-15;/h1-3,5-6,9-12,20H,4,7-8,13-14,19H2,(H,21,22);1H
InChiKey DMYVXSOAWIWRSQ-UHFFFAOYSA-N
CID 91826508
Short Description LSD1 inhibitor

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