CPI 455

Based on 11 reference(s) in Google Scholar 10 10 11

Axon 2573

CAS [1628208-23-0]

MF C16H14N4O
MW 278.31

  • Purity: 99%
  • Soluble in DMSO

CPI 455

Description

Selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation in several cell contexts and reduces survival of drug-tolerant cancer cells. CPI-455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance.

Note: CPI 455 can be used in combination with a less potent control compound, by the authors of the 2016 Nature publication referred to as CPI 4203 (Axon 2622). 

KEYWORDS: CPI 455 | supplier | KDM5 inhibitor | CPI455 | CAS [1628208-23-0] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain

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Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €335.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €520.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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