Bulk Inquiry
JQKD82 dihydrochloride
Axon 3783
- Parent CAS: 2410512-38-6
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C27H40N4O5.2HCl
- MW: 573.55
Description
JQKD82 dihydrochloride is a cell-permeable and selective KDM5 inhibitor which increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a prodrug-type KDM5 inhibitor which delivers the active binding molecule KDM5-C49 to potently block KDM5 function in multiple myeloma cells both in vitro and in vivo (IC50 value of 0.42 μM in MM.1S cells).
More Information
| Parent CAS No. | 2410512-38-6 |
|---|---|
| Chemical Name | 2,4-Diisopropoxyphenyl 2-((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethylamino)methyl)isonicotinate dihydrochloride |
| SMILES | C1(CNCC(=O)N(CC)CCN(C)C)C=C(C(=O)OC2C(OC(C)C)=CC(OC(C)C)=CC=2)C=CN=1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C27H40N4O5.2ClH/c1-8-31(14-13-30(6)7)26(32)18-28-17-22-15-21(11-12-29-22)27(33)36-24-10-9-23(34-19(2)3)16-25(24)35-20(4)5;;/h9-12,15-16,19-20,28H,8,13-14,17-18H2,1-7H3;2*1H |
| InChiKey | LDSXMHKWRLCTDV-UHFFFAOYSA-N |
| CID | 146374976 |
| Short Description | KDM5 inhibitor |
Other Categories
Get a Quote for
Loading...