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ATB 346
- Soluble in DMSO
- MF: C21H19NO3S
- MW: 365.45
Description
Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor and a derivative of Naproxen (significantly reduced exudate leukocyte and PGE2 levels at 30 µmol/kg oral administration). ATB-346 exhibits anti-inflammatory properties similar to naproxen.In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen but with substantially reduced gastrointestinal toxicity (100-fold safer than naproxen).
More Information
| Parent CAS No. | 1226895-20-0 |
|---|---|
| Chemical Name | 4-Carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate |
| SMILES | C1C=C2C=C(C(C)C(=O)OC3C=CC(C(=S)N)=CC=3)C=CC2=CC=1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26) |
| InChiKey | YCNMAPLPQYQJFC-UHFFFAOYSA-N |
| CID | 25065981 |
| Short Description | COX inhibitor; H2S-releasing compound |
References
- M. Campolo et al. A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury. FASEB J. 2013, 27, 4489-4499.
- R. Blackler et al. Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence. PLoS One, 2012, 7(4), e35196.
- J.L. Wallace et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br. J. Pharmacol. 2010, 159(6), 1236-1246.
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