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DLCI-1
- Parent CAS: 2244569-14-8
- Soluble in water and DMSO
- MF: C12H14N2S.2HCl
- MW: 291.24
Description
DLCI-1 is a potent and selective inhibitor of cytochrome P450 2A6 (CYP2A6) with an IC50 value of 0.017 μM. DLCI-1 decreases nicotine self-administration in mice.
More Information
| Parent CAS No. | 2244569-14-8 |
|---|---|
| Chemical Name | (5-(4-Ethylpyridin-3-yl)thiophen-2-yl)methanamine dihydrochloride |
| SMILES | C1C(CC)=C(C2SC(CN)=CC=2)C=NC=1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C12H14N2S.2ClH/c1-2-9-5-6-14-8-11(9)12-4-3-10(7-13)15-12;;/h3-6,8H,2,7,13H2,1H3;2*1H |
| InChiKey | NJQCWEINBOSPQA-UHFFFAOYSA-N |
| CID | 145957229 |
| Short Description | CYP2A6 inhibitor |
References
- YC Chen et al. The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. J Pharmacol Exp Ther. 2020 Jan;372(1):21-29.
- TT Denton et al. Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition. J Med Chem. 2018;61(16):7065‐7086.
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