Clotrimazole - BAY b 5097

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Axon 3163

CAS [23593-75-1]

MF C22H17ClN2
MW 344.84

  • Purity: 98%
  • Soluble in DMSO
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Clotrimazole

Description

Clotrimazole is an orally applicable antifungal substance with broad-spectrum activity. Clotrimazole inhibits the microsomal cytochrome P450 (CYP450)-dependent event 14-α- lanosterol demethylation, which is a vital step in ergosterol biosynthesis by fungi. Moreover, Clotrimazole is a strong inhibitor of epidermal polycyclic aromatic hydrocarbon (PAH) carcinogen metabolism, of the enzyme-mediated binding of PAH to DNA, and of PAH-induced skin cancer. Also, Clotrimazole is a potent inhibitor of epoxide hydrolase activity in vitro with an IC50 value of 0.1 mM.

KEYWORDS: Clotrimazole | supplier | Antifungal agent | BAY b 5097 | BAYb 5097 | BAY-b 5097 | CAS [23593-75-1] | Steroid (Lanosterol 14-α) | Cytochrome P450 | Inhibitor | Enzymes | Polycyclic aromatic hydrocarbon cancer | PAH

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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