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Clotrimazole
- BAY b 5097
- Soluble in DMSO
- MF: C22H17ClN2
- MW: 344.84
Description
Clotrimazole is an orally applicable antifungal substance with broad-spectrum activity. Clotrimazole inhibits the microsomal cytochrome P450 (CYP450)-dependent event 14-α- lanosterol demethylation, which is a vital step in ergosterol biosynthesis by fungi. Moreover, Clotrimazole is a strong inhibitor of epidermal polycyclic aromatic hydrocarbon (PAH) carcinogen metabolism, of the enzyme-mediated binding of PAH to DNA, and of PAH-induced skin cancer. Also, Clotrimazole is a potent inhibitor of epoxide hydrolase activity in vitro with an IC50 value of 0.1 mM.
More Information
| Parent CAS No. | 23593-75-1 |
|---|---|
| Chemical Name | 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole |
| SMILES | C(C1C=CC=CC=1)(C1C(Cl)=CC=CC=1)(C1C=CC=CC=1)N1C=CN=C1 |
| MFCD | MFCD00057220 |
| InChi | InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
| InChiKey | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| CID | 2812 |
| Short Description | Antifungal agent |
References
- M Plempel et al. BAY B 5097, a New Orally Applicable Antifungal Substance With Broad-Spectrum Activity. Antimicrob Agents Chemother (Bethesda) 1969;9:271-4.
- H Mukhtar et al. Clotrimazole, an Inhibitor of Epidermal Benzo(a)pyrene Metabolism and DNA Binding and Carcinogenicity of the Hydrocarbon. Cancer Res 1984 Oct;44(10):4233-40.
- PD Crowley et al. Clotrimazole as a pharmaceutical: past, present and future. J Appl Microbiol. 2014;117(3):611-617.
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