Oxygenases

Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.


[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.

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Axon ID Name Description From price
1977 DMOG Cell-permeable HIF-PHD inhibitor with pro-angiogenic and -osteogenic properties €65.00
2570 FG-2216 Orally active HIF-PHD inhibitor that increases plasma EPO levels in vivo €95.00
2588 FG-4592 New-generation oral HIF-PHD inhibitor €55.00
1948 HIF Phd Inhibitor 4 Inhibitor of Hypoxia Inducible Factor PHD €105.00
1921 IOX2 Inhibitor of Hypoxia Inducible Factor PHD €95.00

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