Oxygenases (subclass of oxidoreductases; EC 1.) are enzymes that incorporate oxygen atoms from O2 into the oxidized products. Dioxygenases are uncommon enzymes that incorporate both atoms of O2 into one substrate. Besides the large family of cytochrome P450-related (CYP) enzymes, this class of oxidoreductases also includes the well-known family of cyclooxygenases (COX, officially known as prostaglandin-endoperoxide synthase (PTGS))[1], but also histone demethylases (JMJD), desaturases and aromatases, and many others.

[1] Cyclooxygenase enzymes: regulation and function. F.A. Fitzpatrick. Curr. Pharm. Des. 2004, 10, 577-588.

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Axon ID Name Description From price
2989 15-LOX-1 inhibitor i472 Inhibitor of 15-lipoxygenase-1 (15-LOX-1) €165.00
2288 ATB 346 Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor €110.00
1919 Celecoxib Selective COX-2 inhibitor €50.00
1974 GW 406381 COX-2 inhibitor €105.00
2312 ML 351 Potent and selective inhibitor of 12/15-lipoxygenase (LOX) €125.00
2873 ML 355 Potent and selective inhibitor of 12-lipoxygenase (LOX) €95.00
2108 SC 236 Selective COX-2 inhibitor €80.00
2844 ThioLox Inhibitor of 15-lipoxygenase-1 (15-LOX-1) €120.00
2106 Valdecoxib Selecive COX-2 inhibitor €80.00

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