Ena21 hydrochloride is a selective and competitive inhibitor of ALKBH5 with an IC50 value of 15.7 μM. Ena21 had little inhibitory activity for fat mass and obesity-associated protein (FTO), which is another N6-methyladenosine demethylation enzyme.

KEYWORDS: Ena21 hydrochloride | ALKBH5 inhibitor | Ena 21 | Ena-21 | CAS [N.A.] | [355816-26-1] | [1046803-57-9] | DNA-RNA | Histone demethylase | Inhibitor | Enzymes | Glioblastoma multiforme | Alpha-ketoglutarate-dependent dioxygenase B (AlkB) homolog 5 | N6-methyladenosine (m6 A) demethylation enzyme | alkB homolog 5 | RNA demethylase