Kinases (Dual Specificity)
Protein kinases fall into three broad classes, characterised with respect to substrate specificity: Serine/threonine-protein kinases, Tyrosine-protein kinases, and Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)[1].
[1] S.K. Hanks et al. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988, 241, 42-52.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1642 | AZ 3146 | MPS1 kinase inhibitor | €80.00 | |
| 1516 | AZD6244 | MEK1 and MEK2 inhibitor | €60.00 | |
| 1999 | AZD8330 | MEK 1 inhibitor | €105.00 | |
| 3697 | Binimetinib | Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2 | €60.00 | |
| 1809 | BIX 02189 | MEK5 inhibitor; ERK5 inhibitor | €110.00 | |
| 3346 | BIX02188 | Potent MEK5 inhibitor | €110.00 | |
| 1808 | BIX02188-Me | MEK5 inhibitor; ERK5 inhibitor | €110.00 | |
| 3934 | CC-671 | Potent and selective dual inhibitor of TTK | Inquire | |
| 2202 | CK2 inhibitor 10 | Potent and ATP-competitive inhibitor of CK2 | €105.00 | |
| 2992 | CTx-0294885 | Broad-spectrum kinase inhibitor | €90.00 | |
| 4056 | DYRK1A inhibitor compound 11 | Highly selective and ligand-efficient Dyrk1A inhibitor | €150.00 | |
| 4148 | GDC-0973 | Orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 | Recently added | Inquire |
| 1761 | GSK 1120212 | MEK1 and MEK2 inhibitor | €70.00 | |
| 2970 | GSK626616 | Potent, orally bioavailable inhibitor of DYRK3 | €120.00 | |
| 3059 | GW 284543 hydrochloride | Selective MEK5 inhibitor | €95.00 | |
| 3627 | Harmine | Potent, selective and ATP-competitive DYRK1A inhibitor | €50.00 | |
| 3538 | INDY | Potent, selective and ATP-competitive inhibitor of Dyrk1A | €110.00 | |
| 2358 | Mps1-IN-2 | Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 | €95.00 | |
| 5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
| 5010 | Naive Stem Cell NHSM inhibitor Set | Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs | €230.00 | |
| 1408 | PD0325901 | MEK1 and MEK2 inhibitor | €50.00 | |
| 1368 | PD184352 | MEK 1 inhibitor | €80.00 | |
| 1223 | PD98059 | MEK inhibitor | €80.00 | |
| 3540 | ProINDY | Prodrug of INDY; Dyrk1A inhibitor | €110.00 | |
| 3874 | RDEA119 | Potent and highly selective small molecule allosteric MEK inhibitor | Inquire | |
| 1629 | Reversine | MPS1 kinase inhibitor | €85.00 | |
| 1122 | SL 327 | MEK1 and MEK2 inhibitor | €80.00 | |
| 2128 | Stem Cell 2i inhibitor Set | Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €90.00 | |
| 2129 | Stem Cell 3i inhibitor Set | Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €130.00 | |
| 5009 | Stem Cell 4i inhibitor Set | Set of Thiazovivin, SB 431542, PD0325901, and CHIR99021 (inhibitors of ROCK, TGF-β, MEK, and GSK-3 resp.) | €170.00 | |