CK2 inhibitor 10

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2202

CAS [1361229-76-6]

MF C18H14N2O4S
MW 354.38

  • Purity: 99%
  • Soluble in DMSO

CK2 inhibitor 10

Description

Potent and ATP-competitive inhibitor of protein kinase (CK2; IC50 values of 32 nM and 46 nM for CK2α and CK2α' respectively). At 0.30 μM, compound 10 exhibited a >50% inhibitory effect against 9 out of 70 other kinases besides CK2α and CK2α′, while at 30 nM >75% inhibition was observed for two other kinases (DYRK1B and FLT3) only.It exhibited potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116, and breast cancer cells MCF-7.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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