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SJ3149
- Soluble in DMSO
- MF: C20H16N4O4
- MW: 376.37
Description
SJ3149 is a potent and selective degrader of CK1α protein, which inhibited MOLM-13 cell growth with an IC50 value of 13 nM and reduced CK1α abundance with DC50 value of 3.7 nM and Dmax 95%.
More Information
| Parent CAS No. | 3026986-17-1 |
|---|---|
| Chemical Name | 3-(5-(1,2-Benzisoxazol-3-ylamino)-1-oxo-2-isoindolinyl)-2,6-piperidinedione |
| SMILES | C1=C(NC2C3=CC=CC=C3ON=2)C=CC2C(=O)N(C3CCC(=O)NC3=O)CC1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H16N4O4/c25-17-8-7-15(19(26)22-17)24-10-11-9-12(5-6-13(11)20(24)27)21-18-14-3-1-2-4-16(14)28-23-18/h1-6,9,15H,7-8,10H2,(H,21,23)(H,22,25,26) |
| InChiKey | AJUZTJBGJWQZFW-UHFFFAOYSA-N |
| CID | 168511381 |
| Short Description | CK1α degrader |
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