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SR 3029
- Soluble in DMSO
- MF: C23H19F3N8O
- MW: 480.45
Description
A potent, highly specific CK1δ/CK1ε inhibitor (IC50 values 44 nM and 260 nM for CK1δ, and CK1ε, respectively), that selectively inhibits breast cancer cell growth and survival. SR-3029 exhibits in vitro and in vivo PK properties suitable for use in xenograft studies of human cancers, including brain cancers.
More Information
| Parent CAS No. | 1454585-06-8 |
|---|---|
| Chemical Name | N-((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine |
| SMILES | N1C2C(=NC(N3CCOCC3)=NC=2NCC2NC3=C(F)C(F)=CC=C3N=2)N(C2=CC=CC(F)=C2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H19F3N8O/c24-13-2-1-3-14(10-13)34-12-28-20-21(31-23(32-22(20)34)33-6-8-35-9-7-33)27-11-17-29-16-5-4-15(25)18(26)19(16)30-17/h1-5,10,12H,6-9,11H2,(H,29,30)(H,27,31,32) |
| InChiKey | CEBMEQPREMCWOL-UHFFFAOYSA-N |
| CID | 60196195 |
| Short Description | CK1δ/CK1ε inhibitor |
References
- M Bibian et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
- LH Rosenberg et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7(318):318ra202.
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