Binimetinib - MEK162

Based on 261 reference(s) in Google Scholar 8 10 261

Axon 3697

CAS [606143-89-9]

MF C17H15BrF2N4O3
MW 441.23

Purity: 99%
Soluble in DMSO

Binimetinib

Description

Binimetinib is a potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1 and MEK2.

AL Patrice et al. Abstract 2515: Preclinical Development of ARRY-162, A Potent and Selective MEK 1/2 Inhibitor. Cancer Res 15 April 2010; 70 (8_Supplement): 2515.

PA Ascierto et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol. 2013 Mar;14(3):249-56.

B Tran et al. The discovery and development of binimetinib for the treatment of melanoma. Expert Opin Drug Discov. 2020 Jul;15(7):745-754.

Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2

Chemical name

5-(4-Bromo-2-fluorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide

Parent CAS No.

[606143-89-9]

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Binimetinib - MEK162

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