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Axon 3538
CAS [1169755-45-6]
MF C12H13NO2SMW 235.30
INDY is a potent, selective and ATP-competitive inhibitor of Dyrk1A with an IC50 and Ki value of 0.24 and 0.18 μM, respectively. INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression. The prodrug form, ProINDY (Axon 3540), is also available..
KEYWORDS: INDY | Supplier | Dyrk1A inhibitor | CAS [1169755-45-6] | Non Selective (Phosphorylation Substrates) | DYRK | Inhibitor | Enzymes | Down syndrome
(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one
[1169755-45-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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