Based on 6 reference(s) in Google Scholar 8 10 6

Axon 3538

CAS [1169755-45-6]

MW 235.30

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO



INDY is a potent, selective and ATP-competitive inhibitor of Dyrk1A with an IC50 and Ki value of 0.24 and 0.18 μM, respectively. INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression. The prodrug form, ProINDY (Axon 3540), is also available..

KEYWORDS: INDY | Supplier | Dyrk1A inhibitor | CAS [1169755-45-6] | Non Selective (Phosphorylation Substrates) | DYRK | Inhibitor | Enzymes | Down syndrome

Potent, selective and ATP-competitive inhibitor of Dyrk1A

Chemical name


Parent CAS No.


Size Unit Price Stock
10 mg €110.00 In Stock
50 mg €380.00 In Stock
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Size Unit Price Stock
2 x 10 mg €180.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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