CC-671 is a potent and selective dual inhibitor of TTK (Human Protein Kinase Monopolar Spindle 1 (hMps1)) / CLK2 (CDC2-like Kinase), with IC50 values of 5 nM and 3 nM, respectively, a unique feature targeting both TTK (mitotic exit) and CLK2 (mRNA splicing). It displays a strong single agent in vivo antitumor efficacy in multiple TNBC (Triple negative breast cancer) xenograft models.

KEYWORDS: CC-671 | Supplier | TTK inhibitor | CC671 | CC 671 | CT-CC671 | CAS [1618658-88-0] | Non Selective (Mitotic spindle checkpoint) | MPS1 Kinase | Inhibitor | Enzymes