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Reversine
- Soluble in DMSO
- MF: C21H27N7O
- MW: 393.49
Description
Reversine is a purine analog reported to induce dedifferentiation of lineage-committed cells and to inhibit mitotic kinases including Aurora kinases and Mps1/TTK.
Reversine is used to study cellular plasticity, mesenchymal progenitor-like states and the relationship between mitotic kinase signaling and cell fate. Its pharmacology is relevant to regenerative biology, stem cell research and cancer cell-cycle studies.
Key Features
- Induces dedifferentiation of lineage-committed cells
- Reported inhibitor of Aurora kinases and Mps1/TTK
- Promotes multipotent mesenchymal progenitor-like phenotypes in model systems
- Useful for linking mitotic signaling to cell fate control
Applications
- Cellular reprogramming and plasticity studies
- Stem cell and regenerative biology research
- Mitotic kinase pharmacology
- Cancer cell-cycle and differentiation assays
More Information
| Parent CAS No. | 656820-32-5 |
|---|---|
| Chemical Name | N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine |
| SMILES | N(C1CCCCC1)C1N=C(NC2C=CC(N3CCOCC3)=CC=2)N=C2NC=NC=12 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27) |
| InChiKey | ZFLJHSQHILSNCM-UHFFFAOYSA-N |
| CID | 210332 |
| Short Description | MPS1 inhibitor |
References
- M Saraiya et al. Reversine Enhances Generation of Progenitor-like Cells by Dedifferentiation of Annulus Fibrosus Cells. Tissue Eng. Part A. 2010, 16(4), 1443–1455.
- S Santaguida etal. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J. Cell Biol. 2010, 190(1), 73-87.
- AM D'Alise et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol. Cancer Ther. 2008, 7(5), 1140-1149.
- L Anastasia et al. Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death and Differentiation 2006, 13, 2042–2051.
- S Chen et al. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 2004, 126, 410-411.
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