Reversine induces differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells; it is a potent mitotic inhibitor of MPS1 kinase, which inhibits the spindle assembly checkpoint in a dose-dependent manner; also acts as A3 adenosine receptor antagonist (Ki: 660 nM) or aurora kinases inhibitor (IC50: 400-500 nM for Aurora A/B/C respectively).

KEYWORDS: Reversine | supplier | MPS1 inhibitor | CAS [656820-32-5] | Non Selective (Mitotic Spindle Checkpoint) | MPS1 Kinase | Inhibitor | Enzymes