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Stem Cell 2i inhibitor Set
Set of 2 Inhibitors
PD0325901 (Axon 1408)
CHIR99021 (Axon 1386)
(2 mg or 5 mg of each inhibitor)
* Two Inhibitors are in powder form (high purity: 99%)
Ready to be reconstituted freshly
to their 10 mM solutions in DMSO respectively.
Expert Recommendation - Ideal 2i for stem cell research!
Description
A convenient set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386); highly recommended conventional 2i inhibitor set, used together for dual inhibition of MAPK signaling and GSK-3 in stem cell research, to enable mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression.
Prime Source Information: CHIR99021 and PD0325901 from Axon Medchem have been procured by many labs as drug standards for generating reliable and reproducible biological data, evidenced by many recent publications. They are highly pure drugs to be perfect 2i in stem cell research. Be right about your drugs!
Read more: Additional Product Information
Show all Axon Ligand™ Sets
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N.A. |
| MFCD | N.A. |
| Short Description | Stem cell inhibitor set |
References
- O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013, 504, 282-286.
- A.A. Mansour et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature. 2012, 488, 409-413.
- C. Tong et al. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nature Protocols 2011, 6, 827-844.
- M. Kawamata et al. Generation of genetically modified rats from embryonic stem cells. Proc. Natl. Acad. Sci. USA. 2010, 107, 14223-14228.
- M.Y. Chang et al. Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells. PLoS One. 2010, 5, e9838.
- Q.L.Ying et al. The ground state of embryonic stem cell self-renewal. Nature. 2008, 453, 519-523.
- List of publications using PD0325901 (Axon 1408) purchased from Axon Medchem
- List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem
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