GDC-0973 - Cobimetinib | RG7420 | XL518

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Axon 4148

CAS [934660-93-2]

MF C21H21F3IN3O2
MW 531.31

  • Purity: 99%
  • Optical purity: >99% e.e.
  • Soluble in 0.1N HCl(aq) and DMSO
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GDC-0973

Description

GDC-0973 is an orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 (MAP2K1 or MEK1). It blocks the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation, and decreased tumor cell proliferation. GDC-0976 is used, in combination with PLX4032 (Axon 1624), in the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.

Keywords: GDC-0973 | Supplier | MEK1 inhibitor | Cobimetinib | RG7420 | XL518 | GDC0973 | GDC 0973 | RG-7420 | RG 7420 | XL-518 | XL 518 | CT-G0973 | CAS [934660-93-2] | MAPK | MEK | Inhibitor | Enzymes

Orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1

Chemical name

(S)-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[934660-93-2]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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