BIX02188

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 3346

CAS [334949-59-6]

MF C25H24N4O2
MW 412.48

Purity: 98%
Soluble in DMSO

BIX02188

Description

Selective and potent MEK5 inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

BIX02188 is a close analogue of BIX02188-Me (Axon 1808) and BIX02189 (Axon 1809).

KEYWORDS: BIX 02188 | supplier | MEK5/ERK5 inhibitor | BIX02188 | BIX-02188 | CAS [334949-59-6] | MAPK | MEK | ERK | Inhibitor | Enzymes | ERK5 | TGFbR1 | dual

RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1), 120–125.

Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.

BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.

E. Razumovskaya et al. Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem. Biophys. Res. Commun. 2011, 412, 307-312.

Potent MEK5 inhibitor

Chemical name

(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide

Parent CAS No.

[334949-59-6]

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5 mg	€110.00	In Stock
25 mg	€350.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

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BIX02188

Description

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Description

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Parent CAS No.

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