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BIX02188
- Soluble in DMSO
- MF: C25H24N4O2
- MW: 412.48
Description
More Information
| Parent CAS No. | 334949-59-6 |
|---|---|
| Chemical Name | (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide |
| SMILES | C1C=C2/C(=C(/NC3C=CC=C(CN(C)C)C=3)C3C=CC=CC=3)/C(=O)NC2=CC=1C(=O)N |
| MFCD | N.A. |
| InChi | InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22- |
| InChiKey | FSZPIAXLCCQFCM-FCQUAONHSA-N |
| CID | 135398492 |
| Short Description | MEK5 inhibitor |
References
- RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1), 120–125.
- Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.
- BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.
- E. Razumovskaya et al. Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem. Biophys. Res. Commun. 2011, 412, 307-312.
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