AZ 3146

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1642

CAS [1124329-14-1]

MF C24H32N6O3
MW 452.55

Purity: 99%
Soluble in DMSO

AZ 3146

Description

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor, with IC50 to be 35 nM for human Mps1 and selectivity against 46 out of a panel of 50 other kinases and only four kinases were inhibited by >40%, namely FAK, JNK1, JNK2, and KIT. AZ3146 overrides the spindle checkpoint

L Hewitt et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex. J. Cell Biol. 2010, 190(1), 25-34.

W Lan and DW Cleveland. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. 2010, 190 (1): 21-24.

MPS1 kinase inhibitor

Chemical name

9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

Parent CAS No.

[1124329-14-1]

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5 mg	€80.00	In Stock
25 mg	€280.00	In Stock

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AZ 3146

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AZ 3146

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