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AZ 3146

Axon 1642
CAS:  1124329-14-1
Purity:  99%
  • Soluble in DMSO
  • MF:  C24H32N6O3
  • MW:  452.55

Description

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor, with IC50 to be 35 nM for human Mps1 and selectivity against 46 out of a panel of 50 other kinases and only four kinases were inhibited by >40%, namely FAK, JNK1, JNK2, and KIT. AZ3146 overrides the spindle checkpoint

More Information

Parent CAS No. 1124329-14-1
Chemical Name 9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one
SMILES C1N=C(NC2C=CC(OC3CCN(C)CC3)=CC=2OC)N=C2N(C3CCCC3)C(=O)N(C)C=12
MFCD N.A.
InChi InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChiKey YUKWVHPTFRQHMF-UHFFFAOYSA-N
CID 56973724
Short Description Mps1 inhibitor

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