BIX02188-Me

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1808

CAS [334951-92-7]

MF C26H26N4O2
MW 426.51

Purity: 99%
Soluble in DMSO

BIX02188-Me

Description

BIX02188-Me is a N-methly analogue of BIX02188 (Axon 3346) and BIX02189 (Axon 1809). BIX02188-ME is a selective dual MEK5 and ERK kinase inhibitor similar to BIX02188 and BIX02189.

RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1), 120–125.

Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.

BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.

E. Razumovskaya et al. Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem. Biophys. Res. Commun. 2011, 412, 307-312.

MEK5 inhibitor; ERK5 inhibitor

Chemical name

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide

Parent CAS No.

[334951-92-7]

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Size	Unit Price	Stock
5 mg	€110.00	In Stock
25 mg	€350.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

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BIX02188-Me

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