Tofacitinib citrate - CP 690550-10

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2072

CAS [540737-29-9]

MF C16H20N6O.C6H8O7
MW 504.49

Purity: 99%
Soluble in DMSO

Tofacitinib citrate

Description

Potent Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis; the citrate salt form of CP 690550 - Tofacitinib (Axon 1338)

AC Papageorgiou et al. Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 2004, 25(11), 558-562.

E Kudlacz et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am. J. Transplant. 2004, 4, 51-57.

E Kudlacz et al. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582, 154-161.

PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Sci. 2003, 302(5646), 875-878.

Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation Immunomodulator JAK-STAT EC 2.7.10.2 JAK

Potent Janus Kinase 3 (JAK3) inhibitor

Chemical name

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate

Parent CAS No.

[477600-75-2]

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10 mg	€115.00	In Stock
50 mg	€385.00	In Stock

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Tofacitinib citrate - CP 690550-10

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Tofacitinib citrate - CP 690550-10

Description

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Parent CAS No.

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