LY 2784544 - Gandotinib

Based on 234 reference(s) in Google Scholar 10 10 234

Axon 2554

CAS [1229236-86-5]

MW 469.94

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

LY 2784544


Potent, selective and ATP-competitive inhibitor of janus kinase 2 (JAK2) tyrosine kinase (IC50 value 20 and 55 nM for inhibition of JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells, respectively), with no significant inhibitory effect on IL-3 stimulated wild-type JAK2-mediated signaling and cell proliferation (IC50 values >1180 nM) A selective tool for suppression of JAK2V617F-induced myeloproliferative neoplasm (MPN) pathogenesis while minimizing effects on hematopoietic progenitor cells. Moreover, LY2784544 induced apoptosis in inflammatory breast cancer spheres through targeting IL-6-JAK-STAT3 pathway; tested positive in Phase I study in patients with myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET).

KEYWORDS: LY 2784544 | supplier | JAK2 Inhibitor | Gandotinib | LY2784544 |CAS [1229236-86-5] | JAK-STATPathway | JAK | Inhibitor | janus kinase | tyrosine kinase | ATP competitive | JAK2V617F | proliferation |  myeloproliferative neoplasm | MNP | apoptosis | inflammatory | myelofibrosis (MF) | polycythemia vera (PV) | essential thrombocythemia (ET)

Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €340.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
2 x 25 mg €540.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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