The immune system is the system of specialized cells and organs that protect an organism from outside biological influences using several strategies, of which early activation of defense is one of the most important. As their name implies, immunomodulators weaken or modulate the activity of the immune system, thereby decreasing the inflammatory response. Natural immunomodulators act to strengthen weak immune systems and to moderate immune systems that are overactive. Plant sterols and sterolins, aloe vera, and ginseng root are examples of natural immunomodulators. Both natural and synthetic immunomodulators are most often used in organ transplantation to prevent rejection of the new organ, and in autoimmune diseases such as rheumatoid arthritis. Since the late 1960s, they have also been used to treat people with inflammatory bowel disease (IBD)[1].
Interestingly, during the late 1800s and early 1900s, many medical practitioners began to recognize infections as serious complications of opiate addiction. Experimental evidence demonstrates the detrimental effects of opiates on immunity in humans and animals. While opiates directly modulate host immunity, their effects on physiological function of nonspecific host mechanisms are thought to also alter immune responses and play an important role in increased susceptibility to infection[2]

[1] U.S.Patil et al. Immunomodulators: a pharmacological review. Int. J. Pharm. Pharmaceutical Sci. 2012, 4 (S1), 30-36.
[2] H. Friedman et al. Microbial infections, immunomodulation, and drugs of abuse.  Clin Microbiol Rev. 2003, 16, 209-219.

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Axon ID Name Description From price
3245 6-Mercaptopurine Purine analog; Immunosuppressant €50.00
3253 6-Thioguanine Purine analog; Immunosuppressant €40.00
1738 AMD 3100 CXCR4 antagonist €90.00
2099 Avridine Lipoidal amine; interferon-inducing and adjuvant properties €80.00
3825 Cordycepin Nucleoside analogue; Anticancer and anti-inflammatory agent €60.00
1338 CP 690550 JAK3 inhibitor €60.00
1485 Fingolimod S1PR1 agonist; Immunosuppressant €60.00
2432 Hydroxychloroquine sulfate Antimalarial drug with immunosuppressive and anti-inflammatory effects €60.00
4048 Iguratimod Orally active DMARD €70.00
1615 KRP 203 S1PR1 agonist Inquire
1970 Laquinimod Selective autoimmune suppressant; Immunomodulator €70.00
1793 Lenalidomide TNFα inhibitor. Immunomodulator. €40.00
1267 MNITMT Immunosuppressant €75.00
3826 NUC-7738 Prodrug of Cordycepin; Anticancer agent €160.00
2199 ONX 0914 Selective inhibitor of LMP7 subunit of the immunoproteasome. €70.00
3307 Pidotimod Orally bioavailable immunostimulant €50.00
2647 Pirfenidone Broad-spectrum anti-inflammatory and anti-fibrosis agent €60.00
2069 Rapamycin Specific inhibitor of mTOR; binds to FKBP12 €85.00
2868 Roquinimex Immunomodulator €125.00
2487 Silibinin Natural flavonolignan, cytoprotectant, antioxidant, and antihepatotoxic agent €40.00
1635 Sotrastaurin PKC inhibitor €50.00
1670 STF 083010 IRE1α inhibitor €95.00
2263 Tacrolimus Potent Calcineurin (Ca2+ dependent protein phosphatase 2B) inhibitor €100.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
2377 Vidofludimus Oral immunomodulatory drug that inhibits dihydroorotate dehydrogenase (DHODH) €125.00

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