WP 1066

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2316

CAS [857064-38-1]

MF C17H14BrN3O
MW 356.22

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO and Ethanol

WP 1066


Potent inhibitor of JAK2 and STAT3 activity (IC50 values 2.3 µM and 5.6 µM, respectively) that showed selective cytotoxicity toward malignant glioma U87-MG and U373-MG cells at much lower doses than its analogue AG 490 (Axon 1378). Furthermore, WP1066 selectively induces apoptosis in malignant glioma cells by downregulating antiapoptotic proteins (Bcl-XL, Mcl-1 and c-myc) and activating Bax, and significantly inhibited the growth of subcutaneous tumors generated from U87-MG cells in mice.

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10 mg €95.00 In Stock
50 mg €285.00 In Stock
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Size Unit Price Stock
2 x 10 mg €140.00 In Stock
2 x 50 mg €440.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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