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PF 956980
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C18H26N6O
- MW: 342.44
Description
More Information
| Parent CAS No. | 1262832-74-5 |
|---|---|
| Chemical Name | ((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone |
| extra_info | . |
| SMILES | C(N1CC[C@@H](C)[C@@H](N(C)C2N=CN=C3NC=CC3=2)C1)(N1CCCC1)=O |&1:4,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H26N6O/c1-13-6-10-24(18(25)23-8-3-4-9-23)11-15(13)22(2)17-14-5-7-19-16(14)20-12-21-17/h5,7,12-13,15H,3-4,6,8-11H2,1-2H3,(H,19,20,21)/t13-,15+/m1/s1 |
| InChiKey | RONMOMUOZGIDET-HIFRSBDPSA-N |
| CID | 53344620 |
| Short Description | JAK3 inhibitor |
References
- A.J. Steele et al. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of (...). Blood 2010, 116(22), 4569-4577.
- P.S. Changelian et al. The specificity of JAK3 kinase inhibitors. Blood, 2008, 111(4), 2155-2157.
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