S3I 201 - NSC 74859

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2313

CAS [501919-59-1]

MW 365.36

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

S3I 201


Potent, cellular STAT3 inhibitor that inhibits Stat3·Stat3 complex formation and Stat3 DNA-binding and transcriptional activities (IC50 value 86 µm for in vitro Stat3–Stat3:DNA disruption). S3I 201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. Additionally, S3I 201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo. S3I 201 showed cytotoxic activity against a wide variety of cancer cell lines (IC50 values ranging from 37.9 to 82.6 μm) through inhibition of the reductases P5, protein disulfide isomerase (PDI), thiol-disulfide oxidoreductase ERp57, and/or Trx.
Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €270.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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