DT-2216
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C77H96ClF3N10O10S4
- MW: 1542.36
Description
DT-2216 is a selective B-cell lymphoma-extra large (Bcl-XL) targeted protein degrader with potential pro-apoptotic, immunomodulating and antineoplastic activities.
Note: This item is currently suspended at the request of the developer. You might request a quotation for contract research synthesis. Please contact us for conditions and more detailed information.
More Information
| Parent CAS No. | 2365172-42-3 |
|---|---|
| Chemical Name | (2S,4R)-1-((S)-2-(7-(4-((R)-3-(4-(N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C(C2CCC(C)(C)CC=2CN2CCN(C3C=CC(C(=O)NS(C4C=CC(N[C@@H](CSC5C=CC=CC=5)CCN5CCN(C(CCCCCC(N[C@@H](C(C)(C)C)C(=O)N6[C@H](C(N[C@@H](C)C7C=CC(C8=C(C)N=CS8)=CC=7)=O)C[C@@H](O)C6)=O)=O)CC5)=C(S(=O)(=O)C(F)(F)F)C=4)(=O)=O)=CC=3)CC2)C=CC=1Cl |&1:29,52,60,63,79,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C77H96ClF3N10O10S4/c1-51(53-18-20-55(21-19-53)70-52(2)82-50-103-70)83-73(96)66-44-61(92)48-91(66)74(97)71(75(3,4)5)85-68(93)16-12-9-13-17-69(94)90-42-36-87(37-43-90)35-33-59(49-102-62-14-10-8-11-15-62)84-65-31-30-63(45-67(65)104(98,99)77(79,80)81)105(100,101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6,7)34-32-64(57)54-22-26-58(78)27-23-54/h8,10-11,14-15,18-31,45,50-51,59,61,66,71,84,92H,9,12-13,16-17,32-44,46-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1 |
| InChiKey | PXVFFBGSTYQHRO-REQIQPEASA-N |
| CID | 139331475 |
| Short Description | Bcl-XL targeted protein degrader |
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