BCL-2 family proteins have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. One class inhibits apoptosis (BCL-2, BCL-XL, BCL-W, MCL1, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1), whereas a second class promotes apoptosis (BAX, BAK and BOK (also known as MTD)). A third divergent class of BH3-only proteins (BAD, BIK (also known as BLK or NBK), BID, HRK (also known as death protein-5 (DP5)), BIM (also known as BOD), BMF, NOXA and PUMA (also known as BBC3)) has a conserved BH3 domain that can bind and regulate the anti-apoptotic BCL-2 proteins to promote apoptosis. Simultaneous over-expression of the anti-apoptotic Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma[1]. ABT-199 (Axon 2141), is a so-called BH3-mimetic drug designed to block the function of the Bcl-2 protein, on patients with chronic lymphocytic leukemia[2].

[1] J.E. Chipuk et al. TheBCL-2 family reunion. Mol Cell. 2010, 37, 299-310.
[2] R.J. Youle, A. Strasser. TheBCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.

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Axon ID Name Description From price
3957 A-1155463 dihydrochloride BH3 mimetic Ligand of BCL protein BCL-XL Inquire
3972 A-1331852 BH3 mimetic Ligand of BCL protein BCL-XL €120.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €70.00
3821 ABT-263 Potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins Inquire
3814 AZD4320 BH3-mimetic inhibitor of BCL-2 protein Inquire
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
3714 BCL-201 dihydrochloride BH3-mimetic inhibitor of BCL-2 protein Inquire
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
3047 BI-6C9 Inhibitor of BID protein €145.00
3295 BIA TMBIM6 antagonist €120.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00
3766 DT-2216 Selective B-cell lymphoma-extra large (Bcl-XL) targeted protein degrader Inquire
2007 HA 14-1 Bcl-2 inhibitor and apoptosis inducer of tumor cells €75.00
3079 NPB Potent, site-specific Bcl-2-associated death promoter (BAD) inhibitor €130.00
4152 Obatoclax B-cell lymphoma-2 (BCL-2) inhibitor Inquire
3068 WEHI-9625 First-in-class, potent, and selective mBAK-mediated apoptosis inhibitor €150.00

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