Bcl

Bcl

BCL-2 family proteins have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. One class inhibits apoptosis (BCL-2, BCL-XL, BCL-W, MCL1, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1), whereas a second class promotes apoptosis (BAX, BAK and BOK (also known as MTD)). A third divergent class of BH3-only proteins (BAD, BIK (also known as BLK or NBK), BID, HRK (also known as death protein-5 (DP5)), BIM (also known as BOD), BMF, NOXA and PUMA (also known as BBC3)) has a conserved BH3 domain that can bind and regulate the anti-apoptotic BCL-2 proteins to promote apoptosis. Simultaneous over-expression of the anti-apoptotic Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma. ABT-199 (Axon 2141), is a so-called BH3-mimetic drug designed to block the function of the Bcl-2 protein, on patients with chronic lymphocytic leukemia.

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  • BH3I 1
    1828
    BH3I 1
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    From $137.50

  • HA 14-1
    2007
    HA 14-1
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    From $82.50

  • ABT 199
    2141
    ABT 199
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    From $77.00

  • BAM 7
    2185
    BAM 7
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    From $99.00

  • BI-6C9
    3047
    BI-6C9
    The price depends on the options chosen on the product page

    From $159.50

  • WEHI-9625
    3068
    WEHI-9625
    The price depends on the options chosen on the product page

    From $165.00

  • NPB
    3079
    NPB
    The price depends on the options chosen on the product page

    From $143.00

  • BIA
    3295
    BIA
    The price depends on the options chosen on the product page

    From $132.00

  • BTSA1
    3431
    BTSA1
    The price depends on the options chosen on the product page

    From $121.00

  • BCL-201 dihydrochloride
    3714
    BCL-201 dihydrochloride
    The price depends on the options chosen on the product page

    From Inquiry

  • DT-2216
    3766
    DT-2216
    The price depends on the options chosen on the product page

    From Inquiry

  • AZD4320
    3814
    AZD4320
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    From Inquiry

  • ABT-263
    3821
    ABT-263
    The price depends on the options chosen on the product page

    From $88.00

  • A-1155463 dihydrochloride
    3957
    A-1155463 dihydrochloride
    The price depends on the options chosen on the product page

    From Inquiry

  • A-1331852
    3972
    A-1331852
    The price depends on the options chosen on the product page

    From $132.00

Items 1-15 of 16

More About Bcl

BCL-2 family proteins have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. One class inhibits apoptosis (BCL-2, BCL-XL, BCL-W, MCL1, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1), whereas a second class promotes apoptosis (BAX, BAK and BOK (also known as MTD)). A third divergent class of BH3-only proteins (BAD, BIK (also known as BLK or NBK), BID, HRK (also known as death protein-5 (DP5)), BIM (also known as BOD), BMF, NOXA and PUMA (also known as BBC3)) has a conserved BH3 domain that can bind and regulate the anti-apoptotic BCL-2 proteins to promote apoptosis. Simultaneous over-expression of the anti-apoptotic Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma[1]. ABT-199 (Axon 2141), is a so-called BH3-mimetic drug designed to block the function of the Bcl-2 protein, on patients with chronic lymphocytic leukemia[2].

[1] J.E. Chipuk et al. TheBCL-2 family reunion. Mol Cell. 2010, 37, 299-310.
[2] R.J. Youle, A. Strasser. TheBCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.

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