Bulk Inquiry
NPB
- Soluble in DMSO
- MF: C29H31Cl2N3O2
- MW: 524.48
Description
NPB is a potent, site-specific inhibitor of Bcl-2-associated death promoter (BAD) phosphorylation with efficacy in tumor models. NPB reduced phosphorylation of BAD-Ser99 and enhanced caspase 3/7 activity with associated loss of cell viability in various human cancer cell lines derived from mammary, endometrial, ovarian, hepatocellular, colon, prostatic, and pancreatic carcinoma.
More Information
| Parent CAS No. | 2247491-97-8 |
|---|---|
| Chemical Name | N-Cyclopentyl-3-((4-(2,3-dichlorophenyl)piperazin-1-yl)(2-hydroxyphenyl)methyl)benzamide |
| SMILES | C1C=CC=C(C(C2C=C(C(NC3CCCC3)=O)C=CC=2)N2CCN(C3C=CC=C(Cl)C=3Cl)CC2)C=1O |
| MFCD | N.A. |
| InChi | InChI=1S/C29H31Cl2N3O2/c30-24-12-6-13-25(27(24)31)33-15-17-34(18-16-33)28(23-11-3-4-14-26(23)35)20-7-5-8-21(19-20)29(36)32-22-9-1-2-10-22/h3-8,11-14,19,22,28,35H,1-2,9-10,15-18H2,(H,32,36) |
| InChiKey | IQLVMUSOSDGQHW-UHFFFAOYSA-N |
| CID | 135363221 |
| Short Description | BAD inhibitor |
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