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ABT-263
- Navitoclax
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C47H55ClF3N5O6S3
- MW: 974.61
Description
ABT-263 is a second-generation potent and orally bioavailable Bcl-2 family inhibitor with Ki values of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
More Information
| Parent CAS No. | 923564-51-6 |
|---|---|
| Chemical Name | (R)-4-(4-((2-(4-Chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide |
| SMILES | C1C(C)(C)CC(CN2CCN(C3C=CC(C(=O)NS(=O)(=O)C4C=CC(N[C@@H](CSC5C=CC=CC=5)CCN5CCOCC5)=C(S(=O)(=O)C(F)(F)F)C=4)=CC=3)CC2)=C(C2C=CC(Cl)=CC=2)C1 |&1:26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1 |
| InChiKey | JLYAXFNOILIKPP-KXQOOQHDSA-N |
| CID | 24978538 |
| Short Description | Bcl-2 family inhibitor |
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