Bulk Inquiry
Erastin
- Soluble in DMSO
- MF: C30H31ClN4O4
- MW: 547.04
Description
Erastin is a ferroptosis-inducing small molecule that promotes oxidative, non-apoptotic cell death by disrupting cystine uptake and redox homeostasis in susceptible tumor cells.
Erastin is associated with inhibition of the system xc− cystine/glutamate antiporter and modulation of mitochondrial VDAC proteins, leading to glutathione depletion and lipid peroxide accumulation. It is a widely used tool for studying ferroptosis and cancer redox vulnerabilities.
Key Features
- Ferroptosis inducer
- Disrupts cystine uptake and glutathione-dependent redox control
- Associated with VDAC2/VDAC3-dependent mitochondrial effects
- Promotes RAS-selective non-apoptotic tumor cell death in sensitive models
Applications
- Ferroptosis pathway research
- Cancer redox vulnerability studies
- System xc−/SLC7A11 and cystine transport assays
- Lipid peroxidation and glutathione depletion models
More Information
| Parent CAS No. | 571203-78-6 |
|---|---|
| Chemical Name | 4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)- |
| SMILES | N1C2=C(C=CC=C2)C(=O)N(C2=CC=CC=C2OCC)C=1C(N1CCN(C(COC2=CC=C(Cl)C=C2)=O)CC1)C |
| MFCD | MFCD09837984 |
| InChi | InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3 |
| InChiKey | BKQFRNYHFIQEKN-UHFFFAOYSA-N |
| CID | 11214940 |
| Short Description | VDAC2 inhibitor |
References
- N Yagoda et al. RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007, 447, 865-869.
- Citation: JF Foley, Selective Killing. Sci. STKE 2007, 391, p. tw212.
- E imamura et al. Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents. J. Bioenerg. Biomembr. 2008, 40(3), 213-217.
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