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ML 210
- CID 49766530
- Soluble in DMSO
- MF: C22H20Cl2N4O4
- MW: 475.32
Description
ML 210 is a chemical probe originally identified as an HRAS synthetic lethal compound with nanomolar activity in HRASG12V-expressing cell models. It is also widely used as a ferroptosis-inducing tool in oxidative cell death research.
RAS-mutant cancer cells can display altered redox and survival dependencies. ML 210 is useful for studying genotype-associated vulnerability, lipid peroxidation-driven cell death and pharmacological mechanisms linking oncogenic RAS to ferroptotic sensitivity.
Key Features
- HRASG12V-selective lethal activity in reported models
- Useful ferroptosis-inducing chemical probe
- Supports oxidative cell death mechanism studies
- Relevant to RAS-mutant oncology research
Applications
- HRAS synthetic lethality screens
- Ferroptosis and lipid peroxidation assays
- Cancer cell vulnerability studies
- Oxidative stress pathway research
More Information
| Parent CAS No. | 1360705-96-9 |
|---|---|
| Chemical Name | (4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone |
| SMILES | C(N1CCN(C(C2=CC=C(Cl)C=C2)C2=CC=C(Cl)C=C2)CC1)(C1C([N+]([O-])=O)=C(C)ON=1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3 |
| InChiKey | VIBHJPDPEVVDTB-UHFFFAOYSA-N |
| CID | 49766530 |
| Short Description | HRAS lethal compound |
References
- JA Bittker et al. Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2. Probe Reports NIH Mol. Lib. Program. PMID: 22834036.
- M Weïwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 2012, 22(4), 1822-1826.
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