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Fendiline hydrochloride
- Parent CAS: 13042-18-7
- Soluble in DMSO
- MF: C23H25N.HCl
- MW: 351.91
Description
Fendiline, an L-type calcium channel blocker (IC50 value of 17 µM), is a specific inhibitor of K-Ras plasma membrane targeting (IC50 value of 9.64 µM) with no detectable effect on the localization of H- and N-Ras. Moreover, Fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras.
More Information
| Parent CAS No. | 13042-18-7 |
|---|---|
| Chemical Name | 3,3-Diphenyl-N-(1-phenylethyl)propan-1-amine hydrochloride |
| SMILES | C1C(C(C)NCCC(C2C=CC=CC=2)C2C=CC=CC=2)=CC=CC=1.Cl |
| MFCD | MFCD00079301 |
| InChi | InChI=1S/C23H25N.ClH/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22;/h2-16,19,23-24H,17-18H2,1H3;1H |
| InChiKey | NJXWZWXCHBNOOG-UHFFFAOYSA-N |
| CID | 5702162 |
| Short Description | KRAS inhibitor |
References
- R Bayer et al. Fendiline: a review of its basic pharmacological and clinical properties. Pharmatherapeutica. 1987;5(2):103-36.
- O Tripathi et al. Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br J Pharmacol. 1993 Apr;108(4):865-9.
- D van der Hoeven et al. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013 Jan;33(2):237-51.
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