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GDC-6036

Name: GDC-6036
SKU: 3768

- Divarasib

Axon 3768

CAS: 2417987-45-0

GDC-6036 is an orally available, potent and selective inhibitor of KRAS G12C mutant.

Parent CAS No.	2417987-45-0
Chemical Name	1-((S)-4-((R)-7-(6-Amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one
extra_info	Sold in collaboration with Chemietek
SMILES	C1(Cl)C=C2C(N3CCN(C(C=C)=O)C[C@@H]3C)=NC(OC[C@@H]3CCCN3C)=NC2=C(F)C=1C1C(C(F)(F)F)=C(C)C=C(N)N=1 \|&1:14,20,r\|
MFCD	N.A.
InChi	InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1
InChiKey	ZRBPIAWWRPFDPY-IRXDYDNUSA-N
CID	146624881
Short Description	KRAS-G12C inhibitor

GDC-6036 KRAS-G12C inhibitor Divarasib GDC6036 GDC 6036 CT-G6036 CAS 2417987-45-0 Axon Medchem Axon 3768 GTP KRAS Inhibitor Enzymes Supplier Vendor

AXON ID	NAME	DESCRIPTION	FROM PRICE
2829	Fendiline hydrochloride	KRAS inhibitor; Ca2+ channel blocker (L-type voltage gated)	From $55.00
3053	BAY-293	Potent, selective and cell-active inhibitor of KRAS-SOS1 interaction	From $154.00
3084	ARS-1620	Potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor	From $159.50
3471	BI-3406	Inhibitor of KRAS/Son of Sevenless 1 (SOS1) interaction	From Inquiry
3575	AMG510	Highly potent, selective, and orally bioavailable KRAS-G12C inhibitor	From $99.00
3733	MRTX1257	Irreversible covalent inhibitor of KRAS G12C	From Inquiry
3761	MRTX1133	First-in-class, noncovalent, selective & reversible inhibitor of KRASG12D mutant	From $242.00
4036	MRTX849	Potent, mutation-selective, and irreversible covalent inhibitor of KRAS-G12C	From $121.00