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BAY-293

Name: BAY-293
SKU: 3053

Axon 3053

CAS: 2244904-70-7

Optical Purity: 100% e.e.

Soluble in DMSO

MF: C25H28N4O2S
MW: 448.58

Description

BAY-293 is a potent, selective and cell-active inhibitor of KRAS-SOS1 interaction with an IC50 value of 21 nM. BAY-293 efficiently inhibited pERK levels in K-562 cells after incubation for 60 min without affecting total protein levels of ERK. A synergistic effect is observed between BAY-293 and ARS-853 in a KRASG12C-mutated cancer cell line.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

KRAS

Parent CAS No.	2244904-70-7
Chemical Name	(R)-6,7-Dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
SMILES	C1(OC)C=C2C(N[C@H](C)C3=CC(C4C=CC=CC=4CNC)=CS3)=NC(C)=NC2=CC=1OC \|&1:7,r\|
MFCD	N.A.
InChi	InChI=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1
InChiKey	WEGLOYDTDILXDA-OAHLLOKOSA-N
CID	137322663
Short Description	KRAS-SOS1 inhibitor

BAY-293 KRAS-SOS1 inhibitor BAY293 BAY 293 CAS 2244904-70-7 Axon Medchem Axon 3053 GTP KRAS Inhibitor Enzymes Son of sevenless SOS1 Supplier Vendor

References

RC Hillig et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560.

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BAY-293

Description

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