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ARS-1620
Axon 3084
CAS:
1698055-85-4
- Optical Purity: 99.2% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H17ClF2N4O2
- MW: 430.84
Description
ARS-1620 is a potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor. ARS-1620 inhibits KRAS with high potency in cells and animals. Moreover, ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression.
More Information
| Parent CAS No. | 1698055-85-4 |
|---|---|
| Chemical Name | (S)-1-(4-(6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one |
| SMILES | C1C=C(O)C(C2C(Cl)=CC3C(N4CCN(C(=O)C=C)CC4)=NC=NC=3C=2F)=C(F)C=1 |&1:4,r,wU:0.0,4.3,(9.16,-8.56,;9.89,-8.56,;10.25,-9.19,;10.98,-9.19,;9.89,-9.82,;10.25,-10.45,;10.98,-10.45,;11.35,-9.82,;11.35,-11.09,;10.98,-11.72,;11.35,-12.35,;12.08,-12.35,;12.44,-11.72,;13.17,-11.72,;13.54,-12.35,;14.27,-12.35,;14.63,-11.72,;14.63,-12.98,;15.36,-12.98,;13.17,-12.99,;12.44,-12.99,;10.98,-12.99,;10.25,-12.99,;9.89,-12.35,;10.25,-11.72,;9.89,-11.09,;9.16,-11.09,;9.16,-9.82,;8.79,-10.45,;8.79,-9.19,)| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2 |
| InChiKey | ZRPZPNYZFSJUPA-UHFFFAOYSA-N |
| CID | 137003167 |
| Short Description | KRAS-G12C inhibitor |
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