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AMG510

 - Sotorasib
Axon 3575
CAS:  2296729-00-3
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C30H30F2N6O3
  • MW:  560.59

Description

AMG510 is a highly potent, selective, orally bioavailable, well-tolerated and covalent KRASG12C inhibitor with an IC50 value of 68 nM (p-ERK).

More Information

Parent CAS No. 2296729-00-3
Chemical Name 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
SMILES C1(=C(C(C)C)N=CC=C1C)N1C(=O)N=C(N2[C@@H](C)CN(C(=O)C=C)CC2)C2C=C(F)C(C3C(F)=CC=CC=3O)=NC1=2 |&1:16,r|
MFCD N.A.
InChi InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChiKey NXQKSXLFSAEQCZ-SFHVURJKSA-N
CID 137278711
Short Description KRAS-G12C inhibitor

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