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CID 1067700
- ML282
- Soluble in DMSO
- MF: C18H18N2O4S2
- MW: 390.48
Description
CID 1067700 (ML282) is the first reported potent inhibitor of Rab7 GTPase, exhibiting nanomolar inhibition of Rab7 guanine nucleotide binding. The compound inhibits both BODIPY-GTP and BODIPY-GDP binding with Ki values of 13 nM and 19 nM and EC50 values of 11 nM and 21 nM, respectively, achieving ≥97% inhibition of nucleotide binding.
Rab7 is a member of the Ras superfamily of small GTPases and plays a central role in late endosomal trafficking, lysosomal biogenesis, autophagy, endosome maturation, and intracellular vesicle transport. CID 1067700 acts as a competitive guanine nucleotide binding inhibitor and provides a valuable chemical probe for studying Rab7-dependent membrane trafficking pathways. As one of the first small-molecule inhibitors targeting Rab GTPases, CID 1067700 has become an important tool for investigating intracellular transport, autophagy, lysosomal function, and GTPase-mediated signaling.
Key Features
- First reported Rab7 GTPase inhibitor
- Ki: 13 nM (BODIPY-GTP) and 19 nM (BODIPY-GDP)
- Competitive guanine nucleotide binding inhibitor
- ≥97% inhibition of Rab7 nucleotide binding
- Useful tool for vesicular trafficking and autophagy research
Applications
- Rab7 signaling and biology research
- Endosomal and lysosomal trafficking studies
- Autophagy investigations
- Intracellular vesicle transport research
- Small GTPase and membrane trafficking studies
More Information
| Parent CAS No. | 314042-01-8 |
|---|---|
| Chemical Name | 2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid |
| SMILES | C1OC(C)(C)CC2C(C(O)=O)=C(NC(NC(=O)C3=CC=CC=C3)=S)SC1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18N2O4S2/c1-18(2)8-11-12(9-24-18)26-15(13(11)16(22)23)20-17(25)19-14(21)10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,22,23)(H2,19,20,21,25) |
| InChiKey | ATSWBWHRHAQVFM-UHFFFAOYSA-N |
| CID | 1067700 |
| Short Description | Rab7 GTPase inhibitor |
