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RBC 8
Axon 2396
CAS:
361185-42-4
Purity:
99%
- Soluble in DMSO
- MF: C25H20N4O3
- MW: 424.45
Description
RBC 8 is an inhibitor of the RAS-like small GTPases RalA and RalB that interferes with binding of GDP-bound Ral proteins to the effector RALBP1. It shows selectivity for Ral relative to Ras and RhoA and inhibits Ral-mediated cell spreading and anchorage-independent growth of cancer cells.
Ral GTPases act downstream of RAS and regulate vesicle trafficking, cytoskeletal behavior and tumorigenic growth. RBC 8 is useful for studying RalA/RalB pharmacology and RAS-effector signaling in cancer models.
Key Features
- RalA/RalB small GTPase inhibitor
- Disrupts Ral–RALBP1 effector binding
- Selective over Ras and RhoA in reported assays
- Inhibits anchorage-independent cancer-cell growth
Applications
- Ral GTPase pharmacology
- RAS-effector pathway research
- Cancer cell-spreading assays
- Anchorage-independent growth studies
More Information
| Parent CAS No. | 361185-42-4 |
|---|---|
| Chemical Name | 6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
| SMILES | N1=C(C2=CC=C3C(=C2)C=CC=C3)C2C(C3=CC(OC)=CC=C3OC)C(C#N)=C(N)OC=2N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29) |
| InChiKey | CLMQBVUFKIKYLU-UHFFFAOYSA-N |
| CID | 6626226 |
| Short Description | RalA/B inhibitor |
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