Bulk Inquiry
Ferrostatin 1
- Fer-1
- Soluble in DMSO
- MF: C15H22N2O2
- MW: 262.35
Description
Ferrostatin 1 is a potent inhibitor of erastin-induced ferroptosis with an EC50 value of 60 nM in HT-1080 cells. It selectively blocks RAS-selective lethal compound-induced ferroptotic cell death without chelating iron, inhibiting protein synthesis or suppressing ERK phosphorylation.
Ferroptosis is an iron-dependent lipid-peroxidation-driven cell-death pathway distinct from apoptosis, necrosis and autophagy. Ferrostatin 1 is a benchmark inhibitor for defining ferroptotic mechanisms in cancer, neurodegeneration and oxidative injury models.
Key Features
- Potent ferroptosis inhibitor
- EC50: 60 nM in HT-1080 cells
- Blocks erastin/RSL-induced cell death
- Does not act through iron chelation or ERK inhibition
Applications
- Ferroptosis pathway research
- Lipid peroxidation studies
- Cancer cell-death assays
- Oxidative injury and neurodegeneration models
More Information
| Parent CAS No. | 347174-05-4 |
|---|---|
| Chemical Name | Ethyl 3-amino-4-(cyclohexylamino)benzoate |
| SMILES | C(OCC)(=O)C1=CC=C(NC2CCCCC2)C(N)=C1 |
| MFCD | MFCD08072959 |
| InChi | InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3 |
| InChiKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
| CID | 4068248 |
| Short Description | Ferroptosis inhibitor |
References
- S.J. Dixon et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012, 149, 1060-1072.
- R. Skouta et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J. Am. Chem Soc. 2014, 136, 4551-4556.
- C. Louandre et al. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int. J. Cancer. 2013, 133, 1732-1742.
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