Bulk Inquiry
ML162
Axon 3896
CAS:
1035072-16-2
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C23H22Cl2N2O3S
- MW: 477.4
Description
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor and ferroptosis inducer.
More Information
| Parent CAS No. | 1035072-16-2 |
|---|---|
| Chemical Name | 2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide |
| SMILES | C1(C=C(Cl)C(OC)=CC=1)N(C(CCl)=O)C(C(NCCC1C=CC=CC=1)=O)C1=CC=CS1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29) |
| InChiKey | UNVKYJSNMVDZJE-UHFFFAOYSA-N |
| CID | 3689413 |
| Short Description | GPX4 inhibitor |
References
- T Luo et al. Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202206277.
- M Weïwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4301 | UAMC-3203 trihydrochloride |
From $104.50 |
| 2293 | Ferrostatin 1 |
From $93.50 |
| 2990 | Liproxstatin-1 |
From $88.00 |
| 3427 | SRS11-92 |
From $99.00 |
| 3611 | RSL3 |
From $99.00 |
| 3617 | 1R,3R-RSL3 |
From $99.00 |
| 4018 | FSEN1 |
From $132.00 |
Other Categories
Get a Quote for
Loading...