Apoptosis

The number of cells in multicellular organism is tightly regulated. Not simply by controlling the rate of cell division, but also by controlling the rate of cell death. If cells are no longer needed, they commit suicide by activating an intracellular death program. This process is therefore called programmed cell death or apoptosis (from a Greek word meaning “falling off,” as leaves from a tree). The intrinsic apoptotic pathway occurs by the release of cytochrome c from mitochondria. The extrinsic apoptotic pathway is caused by the binding of death ligands, such as TNF (tumor necrosis factor), Fas, and TRAIL (TNF-related-apoptosis-inducing ligand), to their corresponding receptors. Although programmed cell death is involved in a number of key biological phenomena, aberrant apoptosis results in diverse human diseases [1]
The amount of apoptosis that occurs in developing and adult animal tissues is surprisingly large. In the developing vertebrate nervous system up to half or more of the nerve cells normally die soon after they are formed. In a healthy adult human, billions of cells die in the bone marrow and intestine every hour. Although this process seems remarkably wasteful -especially as the vast majority are perfectly healthy at the time they kill themselves- programmed cell death plays an important role during embryonic development, as hands and feet, for example, are sculpted by apoptosis: they start out as spadelike structures, and the individual digits separate only as the cells between them die. In other cases, cells die when the structure they form is no longer needed. When a tadpole changes into a frog, the cells in the tail die, and the tail, which is not needed in the frog, disappears. In many other cases, cell death helps regulate cell numbers. In the developing nervous system, for example, cell death adjusts the number of nerve cells to match the number of target cells that require innervation. In all these cases, the cells die by apoptosis as well[2].


[1] B. Alberts, A. Johnson, J. Lewis et al. Molecular Biology of the Cell. 4th edition. New York. Garland Science, 2002. 
[2] D.R. Williams et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew. Chem. Int. Ed. Engl. 2008, 47, 7466-7469.

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Axon ID Name Description From price
3617 1R,3R-RSL3 (negative control) Negative control of 1S,3R-RSL3 as GPX4 inhibitor €90.00
3957 A-1155463 dihydrochloride BH3 mimetic Ligand of BCL protein BCL-XL Inquire
4008 A-1210477 Potent and selective inhibitor of MCL-1 Inquire
3972 A-1331852 BH3 mimetic Ligand of BCL protein BCL-XL €120.00
2141 ABT 199 Potent, orally bioavailable BCL-2-selective inhibitor €70.00
3821 ABT-263 Potent, selective and orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins Inquire
3686 AMG-176 Potent and selective Mcl-1 inhibitor €490.00
3814 AZD4320 BH3-mimetic inhibitor of BCL-2 protein Inquire
4139 AZD5582 dihydrochloride Apoptosis proteins (IAPs) inhibitor Inquire
3731 AZD5991 BH3-Groove binding Mcl-1 inhibitor Inquire
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
3714 BCL-201 dihydrochloride BH3-mimetic inhibitor of BCL-2 protein Inquire
1828 BH3I 1 Inhibitor of Bcl-2 family protein €125.00
3047 BI-6C9 Inhibitor of BID protein €145.00
3295 BIA TMBIM6 antagonist €120.00
4150 Birinapant Bivalent Smac mimetic and potent antagonist for XIAP and cIAP1 inhibitor  Recently added Inquire
2334 BT2 Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor €95.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00
3766 DT-2216 Selective B-cell lymphoma-extra large (Bcl-XL) targeted protein degrader Inquire
4023 Embelin Potent and cell-permeable inhibitor of XIAP €60.00
2293 Ferrostatin 1 Potent inhibitor of erastin-induced ferroptosis €85.00
4018 FSEN1 Uncompetitive FSP1 inhibitor  Recently added €120.00
2007 HA 14-1 Bcl-2 inhibitor and apoptosis inducer of tumor cells €75.00
3902 LCL-161 IAP inhibitor Inquire
2990 Liproxstatin-1 Potent inhibitor of ferroptosis €80.00
3344 LQZ-7I Orally active survivin-targeting inhibitor €90.00
3713 MIK665 BH3-Groove binding Mcl-1 inhibitor Inquire
2823 ML 311 Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim €95.00
3896 ML162 Covalent GPX4 inhibitor; Ferroptosis inducer  Recently added €90.00
3079 NPB Potent, site-specific Bcl-2-associated death promoter (BAD) inhibitor €130.00

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