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ML 311
Axon 2823
CAS:
315698-17-0
Purity:
99%
- Soluble in DMSO
- MF: C23H24F3N3O
- MW: 415.45
Description
ML311 (EU-5346) is a selective small-molecule inhibitor of the anti-apoptotic protein MCL-1 that disrupts the MCL-1–BIM protein–protein interaction with an IC50 value of 0.31 µM. It functions as a BH3-mimetic-like probe and shows substantially weaker activity against BCL-XL in the original profiling.
ML311 reduces viability of MCL-1-dependent cell lines with reported EC50 values in the approximately 0.3–15 µM range and promotes apoptotic signaling. It is useful for studying MCL-1 dependence, mitochondrial apoptosis and mechanisms by which tumor cells evade pro-apoptotic therapies.
Key Features
- Selective MCL-1 inhibitor
- IC50: 0.31 µM
- Active in MCL-1-dependent cell models
- Promotes apoptosis in susceptible cells
Applications
- MCL-1 protein–protein interaction studies
- BCL-2 family research
- Mitochondrial apoptosis assays
- Drug-resistance models
- Lymphoid and breast cancer research
More Information
| Parent CAS No. | 315698-17-0 |
|---|---|
| Chemical Name | 7-((4-Ethylpiperazin-1-yl)(4-(trifluoromethyl)phenyl)methyl)quinolin-8-ol |
| SMILES | C1C=C2C=CC(C(C3C=CC(C(F)(F)F)=CC=3)N3CCN(CC)CC3)=C(O)C2=NC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3 |
| InChiKey | NGAPBLRRJSKIRT-UHFFFAOYSA-N |
| CID | 3384730 |
| Short Description | Mcl-1-Bim interaction inhibitor |
ML311 (EU-5346)
MCL-1 inhibitor
ML311
EU-5346
ML 311
ML-311
Mcl-1
Lymphoid Tumorigenesis
BCL-2
Inhibitor
MCL-1 protein–protein interaction studies
BCL-2 family research
Mitochondrial apoptosis assays
Drug-resistance models
Lymphoid and breast cancer research
apoptosis
mitochondrial function
breast cancer
receptor selectivity
signal transduction
CAS 315698-17-0
Axon Medchem
Axon 2823
Supplier
Vendor
References
- T Bannister et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Apr 16
- DJ Richard et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.
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