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AMG-176

 - Tapotoclax
Axon 3686
CAS:  1883727-34-1
  • Optical Purity:  99% e.e.
  • Soluble in DMSO
  • MF:  C33H41ClN2O5S
  • MW:  613.21

Description

AMG 176 (Tapotoclax) is an orally bioavailable, highly potent and selective Mcl-1 inhibitor, binding reversibly to BH3- groove of the protein with a Ki value in picomolar range. Demonstrate in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. It is currently in clinical evaluation for the treatment of hematologic malignancies.

More Information

Parent CAS No. 1883727-34-1
Chemical Name (3'R,4S,6'R,7'S,8'E,11'S,12'R)-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one
extra_info Sold in collaboration with Chemietek
SMILES C12N3C[C@]4([H])CC[C@@]4([H])[C@@H](OC)C=CC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C(=C1)C=CC=2OC[C@@]1(C2C=CC(Cl)=CC=2CCC1)C3 |t:13,&1:3,7,9,15,17,32,r|
MFCD N.A.
InChi InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1
InChiKey JQNINBDKGLWYMU-GEAQBIRJSA-N
CID 118910268
Short Description Mcl-1 inhibitor

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