More About Mcl-1
The protein Mcl-1 is a member of the BCL-2 family of proteins which have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. Mcl-1 is a member of the class that inhibits apoptosis (together with BCL-2, BCL-XL, BCL-W, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1)[1].
[1] R.J. Youle, A. Strasser. TheBCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.