Mcl-1

The protein Mcl-1 is a member of the BCL-2 family of proteins which have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. Mcl-1 is a member of the class that inhibits apoptosis (together with BCL-2, BCL-XL, BCL-W, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1)[1]


[1] R.J. Youle, A. Strasser. TheBCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.

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Axon ID Name Description From price
2334 BT2 Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor €95.00
2823 ML 311 Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim  Recently added €95.00

2 Item(s)

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