ABBV-467
Axon 4263
CAS:
2287186-66-5
- Optical Purity: 98
- Soluble in DMSO
- MF: C53H51Cl2FN6O9S
- MW: 1037.98
Description
ABBV-467 is a highly potent and selective MCL-1 inhibitor (Ki < 0.01nM). ABBV-467 induces tumor regression in xenograft models of MM and AML when combined with Venetoclax (Axon 2141).
More Information
| Parent CAS No. | 2287186-66-5 |
|---|---|
| Chemical Name | (11R,20R)-23,26-dichloro-14-[[2-[4-[[(2S)-1,4-dioxan-2-yl]methoxy]phenyl]pyrimidin-4-yl]methoxy]-3-(4-fluorophenyl)-24,25-dimethyl-20-[(4-methylpiperazin-1-yl)methyl]-10,18,21-trioxa-4-thia-6,8-diazapentacyclo[20.2.2.12,5.113,17.09,28]octacosa-1(25),2,5,7,9(28),13,15,17(27),22(26),23-decaene-11-carboxylic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C(F)C=CC=1C1SC2N=CN=C3O[C@@H](C(O)=O)CC4C(OC[C@@H](CN5CCN(C)CC5)OC5C(Cl)=C(C)C(=C(C)C=5Cl)C=1C=23)=CC=C(OCC1C=CN=C(C2C=CC(OC[C@H]3COCCO3)=CC=2)N=1)C=4 |&1:15,24,62,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | MCL-1 inhibitor |
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