Bulk Inquiry
YM155
- Sepantronium bromide
- Parent CAS: 753440-91-4
- Soluble in DMSO
- MF: C20H19BrN4O3
- MW: 443.29
Description
More Information
| Parent CAS No. | 753440-91-4 |
|---|---|
| Chemical Name | 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide |
| SMILES | C1C=C2C(=O)C3[N+](CC4N=CC=NC=4)=C(C)N(CCOC)C=3C(=O)C2=CC=1.[Br-] |
| MFCD | N.A. |
| InChi | InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1 |
| InChiKey | QBIYUDDJPRGKNJ-UHFFFAOYSA-M |
| CID | 11178236 |
| Short Description | Survivin suppressant |
References
- A Kita et al. Survivin suppressant: a promising target for cancer therapy and pharmacological profiles of YM155. Nippon Yakurigaku Zasshi 2010, 136(4), 198-203.
- T Iwasa et al. Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs. Br. J. Cancer 2010, 103(1), 36-42.
- T Nakahara et al. YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts. Cancer Res. 2007, 67, 8014-8021.
- R Gonzalez et al. A phase II study of YM155, a novel survivin suppressant, administered by 168 hour continuous infusion in patients with unresectable stage III or stage IV melanoma. J. Clin. Oncol. 2007, 25(18S), 8538.
- T Satoh et al. Phase I Study of YM155, a Novel Survivin Suppressant, in Patients with Advanced Solid Tumors. Clin. Cancer Res. 2009, 15, 3872.
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