Your cart

There are no items in your shopping cart

XL 019

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2231

CAS [945755-56-6]

MF C25H28N6O2
MW 444.53

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

XL 019

Description

Potent, selective, and orally active JAK2 inhibitor (IC50 values 2.2 nM and 214.2 nM for JAK2 and JAK3 respectively), showing a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. XL 019 significantly inhibits downstream markers pSTAT1 and pSTAT3 (ED50 values 42 mg/kg pSTAT1, and 210 mg/kg pSTAT3).
Order
Size Unit Price Stock
5 mg €100.00 In Stock
25 mg €350.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
2 x 25 mg €560.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1338 CP 690550 JAK3 inhibitor €60.00
1378 AG 490 JAK2 inhibitor €65.00
1588 TG 101348 JAK2 inhibitor €80.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €65.00
1681 Momelotinib JAK1 and JAK2 inhibitor €80.00
1778 AZ 960 JAK2 inhibitor €95.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €110.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €70.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €130.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2314 Stattic Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation €50.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €90.00
2517 Napabucasin Oral first-in-class cancer stemness inhibitor that works by targeting STAT3 €105.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
2775 Cerdulatinib Orally active dual Syk/JAK inhibitor €85.00
3671 CEP-33779 Potent, selective and orally bioavailable JAK2 inhibitor €95.00
3813 BMS-911543 Potent, selective and orally active inhibitor of JAK2 Inquire
3855 AZD-4205 Selective and ATP-competitive inhibitor of JAK1 Inquire
3950 Peficitinib Potent and orally bioavailable JAK inhibitor €120.00
3997 ASN-002 Potent dual inhibitor of SYK and pan-JAK kinases Inquire
4006 GLPG-0634 The first orally-available, selective inhibitor of JAK1 Inquire
4124 Momelotinib hydrochloride JAK1 and JAK2 inhibitor €120.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...