XL 019

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2231

CAS [945755-56-6]

MF C25H28N6O2
MW 444.53

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

XL 019


Potent, selective, and orally active JAK2 inhibitor (IC50 values 2.2 nM and 214.2 nM for JAK2 and JAK3 respectively), showing a significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. XL 019 significantly inhibits downstream markers pSTAT1 and pSTAT3 (ED50 values 42 mg/kg pSTAT1, and 210 mg/kg pSTAT3).
Size Unit Price Stock
5 mg €100.00 In Stock
25 mg €350.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
2 x 25 mg €560.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...